Research Graphic Abstract - Nutrition and Metabolism

Anti-Inflammatory Activity of Gynura bicolor Ether Extract through Inhibits Nuclear Factor Kappa B Activation

Gynura bicolor (Roxb. & Willd.) DC. ether extract (GBEE) can suppress activation of NF-κB to inhibit NO and PGE2 production in the LPS-induced inflammatory response by RAW 264.7 cells.

Induction of Necrosis in Human Liver Tumor Cells by α-Phellandrene

α-PA induced necrosis of human liver tumor cells (J5) through increased ATP depletion via enhanced NO and ROS production and LDH leakage. It suggested that α-PA has chemopreventive and cancer therapeutic potential.

Induction of alpha-phellandrene on autophagy in human liver tumor cells

α-PA is able to induce autophagy in J5 cells lead human liver cells death. The molecular mechanism were through regulate the mTOR, Beclin-1, LC3-II and p53 expression during autophagy induction.

Sedanolide induces autophagy through the PI3K, p53 and NF-κB signaling pathways in human liver cancer cells

Sedanolide (SN), a phthalide-like compound from celery seed oil, 250 and 500 μM SN induce autophagy in J5 cells, leading to human liver cancer cell death. The molecular mechanism involves regulation of PI3K, p53 and NF-κB expression during autophagy induction.

Carnosine suppresses human colorectal cancer cell proliferation by inducing necroptosis and autophagy and reducing angiogenesis

Suppressive Effects of the Gynura bicolor Ether Extract on Endothelial Permeability and Leukocyte Transmigration in Human Endothelial Cells Induced by TNF-α

Suppression of Carnosine on Adhesion and Extravasation of Human Colorectal Cancer Cells

Panax notoginseng Suppresses Bone Morphogenetic Protein-2Expression in EA.hy926 Endothelial Cells by Inhibiting theNoncanonical NF-B and Wnt/-Catenin Signaling Pathways