Suppressive Effects of the Gynura bicolor Ether Extract on Endothelial Permeability and Leukocyte Transmigration in Human Endothelial Cells Induced by TNF-α

GBEE had a potential protective effect against atherosclerosis via suppression of leukocyte-endothelium transmigration. Figure 6 shows that GBEE inhibited adhesion molecules and junction protein expression via inhibition of NF-κB signalling and reduced leukocyte adhesion to endothelial cells ability and endothelial monolayer permeability, which led to the downregulation of adhesion and transmigration-regulated molecular expression. GBEE reduced paracellular and transcellular transmigration to maintain cell-cell monolayer integrity, reduce permeability, and prevent endothelial dysfunction.

DOI: 10.1155/2020/9413724